Acivir 200 mg

Active mechanism

In order become effective, aciclovir has changed to go only to mono-phosphate by an enzyme, found only in viruses, called thymidine kinase (TK) is acyclovir become. Then his active triphosphate form is converted by enzymes in the human cells found.

CMV produces no thymidine kinase, so that the antiviral activity of aciclovir in CMV infections is bad.

Acyclovir triphosphate (AT) is the active form of the drug. It reduces the production of virus DNA, from competing with a natural material, Deoxyguanosine triphosphate, for the viral DNA polymerase enzyme. Installation of AT in the viral DNA completely prevents, that the new synthesis of DNA.

Viral DNA polymerase binds 10-30 sometimes stronger than the cellular DNA polymerase from AT. Diese means, acyclovir is not toxic.

Unfortunately, only about 15-20% of the dose are absorbed by the intestinal wall by acyclovir, that is, they often have to go like it only seized, Actively for two or three hours become in the blood stream.

Acivir for treatment of the virus herpes simplex infections of the skin and mucous membranes, including initial and recurrent genital herpes, suppression of recurrent herpes simplex infections in immunocompetent patients, herpes simplex infection prophylaxis in

immunocompromised patients; varicella (pox chicken) and herpes zoster infections (shingles), and management of severely immunocompromised, namely those with HIV disease (CD4 counts <200/mm 3, including patients with AIDS or strict ARC), or after bone marrow transplantation.

Warnings / precautions

Use no Acivir, if:

They are against any allergic ingredients in Acivir;

If you are pregnant, plan a gestation or breastfeed;

If you to itself in it, the prescription drugs or not liable to prescription, vegetable preparation or food supplement medicine;

if you allergies on drugs, food or other materials;

If you have kidney problems or a weak immune system

Contact your doctor or supplier immediately if one of these points apply to you.

Some medical conditions can interoperate Acivir with capsules. Inform your doctor or chemist, some medical conditions if you, above all if one of the following points applies to you:

If you are pregnant, a plan or breastfeed gestation

If you to itself in it, the prescription drugs or not liable to prescription, vegetable preparation or food supplement medicine

if you allergies on drugs, food or other materials

If you have kidney problems or a weak immune system

Some drugs are able to do with Acivir capsules. Inform your doctor if you take other drugs, above all of one of the following qualities:

The drugs which could damage the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, non-steroid anti-inflammatory drugs ale [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk can be raised by kidney stones side effects . Ask your doctor if you are unsafe Whether your all drugs could damage the kidneys will